When the Brain Refuses Your Categories: Sapolsky and the Neuro-Biology of Transness

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Looking through some of the drafts clogging the blog, I decided to whittle away at the queue. I started this months ago. It’s here now, not particularly in sync with the season or recent topics, but I like Sapolsky.

‘Biology is destiny’, say the Christian Right, the bland bureaucrats of morality, the loud whisperers at Sunday school. They want gender to be a tomb carved in marble: you’re assigned at birth, and you stay a perfect statue. But Sapolsky waltzes in and says, ‘Hold up – what do you mean by biology? Which biology? Which markers count?’

Video: Neuro-biology of Transsexuality, Prof. Robert Sapolsky

In the clip above, Sapolsky unpacks neurological evidence that upends the essentialist cheat codes. He doesn’t pretend we now have the final answer to gender. He does something scarier to fundamentalists: he shows just how messy biology is.

The Bed Nucleus, the Finger Ratio, and the ‘Wrong Body’ Hypothesis

Sapolsky discusses three pieces of neurobiological evidence:

  1. Digit ratio (2nd vs 4th finger length): In lesbians, on average, the ratio is closer to what you see in straight men than straight women. That’s a correlation, an eyebrow-raiser, hardly a decree.
  2. Acoustic reflexes (auto-acoustic reflex): Another early finding in women’s sexual orientation, though faint and underexplored.
  3. The bed nucleus of the stria terminalis (BSTc): Here we reach heavy artillery. There is a neuron population in this region that, on average, is about twice as large in males as in females. In postmortem analyses of trans women (male → female), this region’s size corresponds to their identified gender, not their natal sex. Crucially, that alignment is seen even in trans individuals who never underwent full hormone therapy or surgical changes.
    • Sapolsky recounts astute controls: men treated (for, say, testicular cancer) with feminising hormones don’t show the same shift.
    • Also, using the phantom-limb analogy: men who lose their penis to cancer often report phantom sensations; trans women rarely do. That suggests the body map in the brain never fully “registered” that organ in the same way.

He doesn’t overclaim. He doesn’t say, ‘Case closed, biology proves everything’. He says: These data complicate your neat categories. They force you to ask: which biological measure do you privilege? Hypertrophied neurons? Chromosomes? Receptor density? Hormones? All of them simultaneously? None of them?

Essentialism as a Trap

Fundamentalists and anti-trans ideologues deploy essentialism because it’s convenient. They demand an ironclad ‘essence’ so they can exclude anyone who fails their test. But what Sapolsky shows is that essence is simply a scaffold; we get to pick which biological scaffolds we accept. They may choose genes and genitals; the neurobiologist gives them neuron counts and brain-maps. When your ideology elevates one scaffold and ignores the others, it betrays its own contingency.

Moreover, the evidence suggests that identity, experience, insistence (in Sapolsky’s language: ‘insisting from day one’), and internal brain structure might converge. The ‘wrong body’ isn’t a metaphor. It’s a mismatch between internal brain architecture and external form. The stubborn fragments of biology that fundamentalists accept are torn by the dissonance that science increasingly reveals.

What This Means for Trans Rights, Discourse & Strategy

  • Science is never ‘conclusive’. Sapolsky offers compelling support, not gospel. Anyone claiming this settles everything has never looked at a scatter plot.
  • Lived experience still matters. Even if we never had brain slices, self-reports, psychology, psychiatry, anthropology, narratives remain valid. Brain studies supplement, not supplant, testimony.
  • Essentialist opponents have boxed themselves in. When they demand biology decides everything, they hand the baton to neuroscientists – and neuroscientists keep running with it. The entire ‘biology’ equals only what I like’ regime is exposed.
  • Ambiguity is a strength, not a liability. If we insist identity is linear and tidy, we re-enact their demand for purity. Recognising complexity, mess, and variance is radical resistance.

The Morality We Can’t Stop Wanting

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Humans can’t seem to stop clawing after morality. The primates among us chuck cucumbers when their neighbours get grapes, and the rest of us grumble about fairness on social media. The impulse is practically universal, an evolutionary quirk that kept us from throttling each other long enough to raise children and build cities.

Image: A seemingly perturbed capuchin monkey.

But universality is not objectivity. Just because every ape howls about fairness doesn’t mean “Justice” floats somewhere in Platonic space, waiting to be downloaded. It only means we’re the kind of animal that survives by narrating rules and enforcing them with shunning, shame, or, when necessary, cudgels.

Audio: NotebookLM podcast on this topic.

This is where Alasdair MacIntyre trips over his own robes. After Virtue skewers Enlightenment rationalists who tried to prop morality on reason, it then dismisses Nietzsche for being “irrational.” MacIntyre’s fix? Resurrect Aristotle’s teleology. If reason can’t save morality, maybe an ancient oak tree can. But this is wish-thinking with a Greek accent. He’s still arguing by reason that reason can’t do the job, then sneaking back in through Aristotle’s back door with a “firmer ground.” Firmer only because he says so.

Nietzsche, at least, had the decency to call the bluff: no telos, no floor, no cosmic anchor. Just will, style, and the abyss. Uncomfortable? Absolutely. Honest? Yes.

Deleuze went further. He pointed out that morality, like culture, doesn’t look like a tree at all. It’s a rhizome: tangled, proliferating, hybridising, never grounded in a single root. The fragments MacIntyre despairs over aren’t evidence of collapse. They’re evidence of how moral life actually grows—messy, contingent, interconnected. The only reason it looks chaotic is that we keep demanding a trunk where only tubers exist.

So here we are, apes with a craving for rules, building cities and philosophies on scaffolds of habit, language, and mutual illusion. We are supported as surely as the Earth is supported – by nothing. And yet, we go on living.

The need for morality is real. The yearning for telos is real. The floor is not.

« Je pense, donc j’ai raison ! »

3–4 minutes

The Enlightenment promised a universal Reason; what we got was a carnival mirror that flatters philosophers and fools the rest of us. MacIntyre and Anscombe diagnosed the corpse with precision, but then tried to resurrect it with Aristotelian or theological magic tricks. I’m less charitable: you can’t will petrol into an empty tank. In my latest essay, I put ‘Reason’ on the slab, call in Kahneman, Hume, Nietzsche, and others as expert witnesses, and deliver the verdict: morality is a house rule, not a cosmic law. This piece is part of a larger project that includes my Language Insufficiency Hypothesis and Against Dumocracy. The Enlightenment isn’t dying – it’s already dead. We’re just cataloguing the remains.

The Enlightenment was many things: a bonfire of superstition, a hymn to autonomy, a fever dream of “Reason” enthroned. Its philosophers fancied themselves heirs to Aristotle and midwives to a new humanity. And to be fair, they were clever enough to trick even themselves. Too clever by half.

Alasdair MacIntyre, in After Virtue, plays the role of forensic pathologist with admirable precision. He shows us how the Enlightenment dynamited the teleological scaffolding of Aristotle, then tried to keep the vocabulary of virtue, duty, and rights standing in mid-air. The result: what he calls a “moral Babel,” a chorus of shrill assertions dressed up as rational law. Elizabeth Anscombe had already filed the death certificate back in 1958 with Modern Moral Philosophy, where she pointed out that our talk of “moral obligation” is just a Christian relic without a deity to enforce it. And Nietzsche, that perennial party-crasher, cheerfully declared the whole project bankrupt: once the gods are dead, “ought” is nothing but resentment pretending to be metaphysics.

And yet, when MacIntyre reaches the heart of the matter, he can’t quite let the body stay buried. He wants to reattach a soul by importing an Aristotelian telos, even summoning a “new St Benedict” to shepherd us through the ruins. It plays beautifully with those still tethered by a golden string to Aquinas and the premodern, but let’s be honest: this is just hypnosis with a Latin chorus. Descartes told us je pense, donc je suis; MacIntyre updates it to je pense, donc j’ai raison. The trouble is that thinking doesn’t guarantee rightness any more than an empty petrol tank guarantees motion. You can will fuel into existence all you like; the car still isn’t going anywhere.

The behavioral economists – Kahneman, Tversky, Ariely, Gigerenzer – have already demonstrated that human reason is less compass than carnival mirror. Jonathan Haidt has shown that our “moral reasoning” usually lags behind our gut feelings like a PR department scrambling after a scandal. Meanwhile, political practice reduces “just war” to a matter of who gets to publish the rule book. Progress™ is declared, rights are invoked, but the verdict is always written by the most powerful litigant in the room.

So yes, MacIntyre and Anscombe diagnose the corpse with impressive clarity. But then they can’t resist playing resurrectionist, insisting that if we only chant the right metaphysical formula, the Enlightenment’s heart will start beating again. My own wager is bleaker – or maybe just more honest. There is no golden thread back to Aristotle, no metaphysical petrol station in the desert. Morality is not a universal constant; it’s a set of rules as contingent as the offside law. Killing becomes “murder” only when the tribe – or the state – says so. “Life is sacred” is not a discovery but a spell, a linguistic sleight of hand that lets us kill in one context while weeping in another.

The Enlightenment wanted to enthrone Reason as our common oracle. Instead, it handed us a corpse and told us to pretend it was still breathing. My contribution is simply to keep the coroner’s mask on and say: The magic tricks aren’t working anymore. Stop looking for a metaphysical anchor that isn’t there. If there’s to be an “after,” it won’t come from another Saint Benedict. It will come from admitting that the Enlightenment died of believing its own hype – and that language itself was never built to carry the weight of gods.

A Critique of Reason (Not to Be Confused with Kant’s)

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Kant, bless him, thought he was staging the trial of Reason itself, putting the judge in the dock and asking whether the court had jurisdiction. It was a noble spectacle, high theatre of self-scrutiny. But the trick was always rigged. The presiding judge, the prosecution, the jury, the accused, all wore the same powdered wig. Unsurprisingly, Reason acquitted itself.

The Enlightenment’s central syllogism was never more than a parlour trick:

  • P1: The best path is Reason.
  • P2: I practice Reason.
  • C: Therefore, Reason is best.

It’s the self-licking ice-cream cone of intellectual history. And if you dare to object, the trap springs shut: what, you hate Reason? Then you must be irrational. Inquisitors once demanded heretics prove they weren’t in league with Satan; the modern equivalent is being told you’re “anti-science.” The categories defend themselves by anathematising doubt.

The problem is twofold:

First, Reason never guaranteed agreement. Two thinkers can pore over the same “facts” and emerge with opposite verdicts, each sincerely convinced that Reason has anointed their side. In a power-laden society, it is always the stronger voice that gets to declare its reasoning the reasoning. As Dan Hind acidly observed, Reason is often nothing more than a marketing label the powerful slap on their interests.

Second, and this is the darker point, Reason itself is metaphysical, a ghost in a powdered wig. To call something “rational” is already to invoke an invisible authority, as if Truth had a clerical seal. Alasdair MacIntyre was right: strip away the old rituals and you’re left with fragments, not foundations.

Other witnesses have tried to say as much. Horkheimer and Adorno reminded us that Enlightenment rationality curdles into myth the moment it tries to dominate the world. Nietzsche laughed until his throat bled at the pretence of universal reason, then promptly built his own metaphysics of will. Bruno Latour, in We Have Never Been Modern, dared to expose Science as what it actually is – a messy network of institutions, instruments, and politics masquerading as purity. The backlash was so swift and sanctimonious that he later called it his “worst” book, a public recantation that reads more like forced penance than revelation. Even those who glimpsed the scaffolding had to return to the pews.

So when we talk about “Reason” as the bedrock of Modernity, let’s admit the joke. The bedrock was always mist. The house we built upon it is held up by ritual, inertia, and vested interest, not granite clarity. Enlightenment sold us the fantasy of a universal judge, when what we got was a self-justifying oracle. Reason is not the judge in the courtroom. Reason is the courtroom itself, and the courtroom is a carnival tent – all mirrors, no floor.